Staff Bioinformatics Scientist, Algorithm Development

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early-stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

The Staff Bioinformatics Scientist will be proficient in collaborative, integrative, data-driven, computational analysis necessary to develop, launch, and innovate in all aspects of high-throughput oncology test product development and Real World Evidence analysis. As a part of the Bioinformatics and Oncology teams, you will have the opportunity to innovate and implement your ideas to constantly improve our product and analytics so that they are best suited for the changing landscape of clinical needs. 
 
Essential Duties and Responsibilities: 

• Design, prototype, and analyze statistical modeling approaches on NGS data
• Communicate analysis results to stakeholders across computational and experimental teams
• Take ownership of exploratory projects and identify potential new product features
• Contribute to a highly collaborative work environment, participating in brainstorming sessions and maintaining a motivating work environment
• Develop reproducible analyses for research and development activities
• Work with molecular biologists to troubleshoot and analyze technology development experiments from concept through launch.   
• Write clear and precise reports for a technical audience.  
• Work with members of the bioinformatics group, medical affairs, and epidemiologists to conduct integrative analysis with clinical data.
• Mentor junior bioinformatics staff on the team.  
   

• Dedicated to make a difference in a rapid-paced environment
• Ph.D. in bioinformatics, computational biology, statistics, mathematics, computer science or related field
• 4+ years experience in industry/academia post-graduation
• Experience with analysis of high-throughput sequencing data in the context of genomics, epigenomics or other applications.
• Strong background in statistical fundamentals and analysis, including inference approaches and iterative model development
• Experience developing and implementing novel methods in an open-ended data-limited setting
• Proficiency with a high level scripting language (e.g. Python, R)
• Proficiency with Linux command-line and version control tools (git and GitHub)
• Excellent communication skills in an interdisciplinary environment
• Familiar with regulated development environments  

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Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.