Clinical Genomics Scientist, Oncology



Full Time
8mo ago

Do you want to join one of the fastest-growing molecular diagnostics startups and be a pioneer for an industry-leader who is impacting the lives of millions?

BillionToOne, ranked at the top 5% of Y Combinator companies with $250M+ in funding from prominent VC firms, has developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000 fold. BillionToOne's first product, UNITY™ is the first and only non-invasive prenatal test that can directly screen an unborn baby's risk for common and severe recessive gene disorders and chromosomal abnormalities, as well as fetal sex and fetal antigens, from a single tube of blood from the pregnant mother without paternal testing.

In 2023, BillionToOne launched two liquid biopsy products that will markedly improve oncology treatment and care. With Northstar Select™, clinicians will be able to select cancer therapies that will be most effective to each patient based on their individual genetic makeup. Northstar Response™ will enable clinicians to monitor a patient’s early response to these cancer therapies, by measuring minute changes in their ctDNA, which can reduce ineffective treatments and unw

BillionToOne is looking for a Clinical Genomics Scientist, Oncology to help contribute to somatic mutation variant interpretation and reporting. BillionToOne has recently launched two oncology liquid biopsy products: Northstar Select™ and Northstar Response™ for late-stage solid-tumor cancer patients. Northstar Select™ is a comprehensive pan-cancer somatic mutation profiling panel. Northstar Response™ is a methylation-based, tissue-agnostic treatment response monitoring assay.

As an early member of the oncology clinical genomics team, you are responsible for helping with day-to-day commercial reporting operations, including variant interpretation and report drafting. Working closely with the medical team, you will help develop interpretation and reporting policies based on the latest publications and guidelines, and help scale-up our ever growing reporting needs. You will also work closely with the medical, R&D, engineering, clinical lab, and product team to help with curation-based projects to help with product development and launches. This role is a part-time contracting position (10-20 hrs/week) and will report to the Senior Clinical Genomics Scientist, Oncology in a remote-based position. We are looking for someone with long-term engagement interests and able to commit to a minimum of 6 months or longer/strong preference for someone who is able to commit to weekend hours.

If you have a strong commitment to improving patient care through clear clinical reporting, have experience in somatic variant interpretation and report drafting, love diving into literature, enjoy digging into the technical side of the data alongside bioinformatics, and thrive in a fast-paced entrepreneurial environment, this could be a perfect opportunity for you.

Key Responsibilities:

  • Somatic variant interpretation review: Review the variant interpretation results on the curation platform, diving into the literature and variant databases as needed to classify variants for reporting, performing verification as required with BAM file analysis.
  • Clinical report drafting: Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language.
  • Somatic mutation interpretation and reporting policy development: Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation policies in accordance with ACMG/AMP guidelines, and the latest published literature.
  • Contribute to oncology R&D: Work closely with the R&D team to help with somatic oncology based curation projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses.


  • Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field 
  • 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation and 1+ years of somatic variant interpretation experience)
  • Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
  • Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools
  • Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered “hot targets” for drug development, etc.)
  • Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
  • Excellent communication skills and ability to work collaboratively with cross-functional teams

At BillionToOne, we are proud to offer a combination of (1) competitive base pay, and (2) the opportunity for professional growth.

For this position, the target hourly rate is: $100/hour.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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Onkar By: Onkar