Staff Software Engineer, Bioinformatics


Guardant Health

Redwood City, CA
Full Time
3y ago

Company Description

Company Description

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

Job Description

The Work

This individual will contribute to development of software and bioinformatics analysis pipelines used to process patient samples and analyze their genomic profiles based on a simple blood draw. This position is part of a high impact team responsible for developing core data analysis and software capabilities for the industry leading cancer diagnostic products offered by Guardant health. This position is responsible for design, implementation, optimization and testing of software components and data analysis pipelines. This position collaborates with Guardant Health’s research and development teams and contributes to development of products that enhance Guardant Health’s leadership position in cancer testing.

Essential Duties and Responsibilities:

  • Develop software using Python or C++ in Unix based environment with focus on high performance, robustness, and extensibility.
  • Contribute to proto-typing, development, optimization and validation of bioinformatics analysis algorithms using R, Python and C++.
  • Provide written documentation and specifications of software products and services.  Preferably in a regulated environment such as IVD or CLIA.
  • Contribute to all aspects of software development in an agile environment including documentation, design, development, and testing of features and sub-systems.
  • Work collaboratively with scientists to comprehend project objectives, analyze problems, and evaluate and provide informatics solutions.
  • Innovate and contribute to development of novel technologies to help advance genomics research and precision medicine.


  • M.S. in Computer Science or related field or equivalent experience.
  • 8+ years’ experience developing software in Unix based environments using programming languages like C++ and Python.
  • Demonstrated expert knowledge using object-oriented programming and design patterns in production environments.
  • Working knowledge of tools like Jenkins, Docker (or other virtualization technologies).
  • Experience with developing software or data analysis algorithms in the field of Bioinformatics with familiarity to standard bioinformatics tools and file formats is strongly preferred.
  • Understanding of concepts like Next Generation Sequencing, Oncology, Liquid biopsies etc., is helpful but not mandatory.
  • The following experience is not required but is highly desired: working with compute clusters (SGE, HPC, Mesos, etc.), AWS.
  • Effective communicator with written and verbal fluency in English.
  • Self-motivated individual with ability to work well as part of a team in a rapid-pace startup environment.


Additional Information

Employee may be required to lift routine office supplies and use office equipment.  Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment.  Ability to sit for extended periods of time.

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.


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Onkar By: Onkar