Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

The Bioinformatics Scientist, II will help support the bioinformatics and technology development teams to maintain and develop the Guardant tissue test. As a part of the Tissue Technology team, you will have the opportunity to innovate and implement your ideas to constantly improve our product and analytics so that they are best suited for the changing landscape of clinical needs. You will be part of a tightly integrated team of wet lab and computational innovators who are dedicated to creating the best comprehensive genomic profiling solution for all cancer patients. 

Essential Duties and Responsibilities:

• Provide analytic support to Tissue Technology Development and Clinical Operations
• Work with a variety of Technology Development scientists to design and analyze development experiments for new platforms and analytes.
• Work with members of the bioinformatics group, medical affairs, and research scientists to conduct relevant analysis regarding clinical data and the performance of bioinformatics products.
• Explore tissue genomic data from clinical and research samples and external annotation sources to enhance quality of clinical reporting.
• Develop scripts for research and development activities.
• Work together with our collaborators in industry, hospitals and academia on high-impact translational research using Guardant Health tests and publish on findings. 

• Ph.D. in computational biology/bioinformatics, genomics, machine learning, or related fields OR MS and 3+ years industry/academia experience.

• Knowledge of cancer genomics and tumor biology

• Knowledge of high-throughput sequencing methods
• Experience with Human genetics and Cancer genetics databases e.g. (ExAC, ClinVar)
• Experience using scripting languages (R, Python or Shell)
• Knowledge of standard bioinformatics tool e.g. SAMtools, Picard, etc.
• Working knowledge of statistical methods
• Great communication and presentation skills, ability to present clearly and effectively to stakeholders across organizations
• Ability to work well in a fast-paced startup environment
• Desire and ability to dig deeply through various data types to seek out answers
• Strong team player with the the ability to work together in a team, cross-functionally, and even across institutions.

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Covid Vaccination Policy:  Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant’s COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws.  An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

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Please visit our career page at: http://www.guardanthealth.com/jobs/